It would be interesting to know that six out of the last nine home wins in Europe by the Gunners have been by four or more goals, so many expect this to happen in this fixture.
Moreover, AC Milan have unfortunately always been knocked out at this stage in the Champions League for the past four seasons which places much pressure to them today as they try to break that losing streak.
So let's see if we'll witness history unfold and a team finally manages to overturn a four-goal deficit over two-legs in the Champions League.
For Arsenal, the probable lineups would be Szczesny, Sagna, Vermaelen, Koscielny, Gibbs, Rosicky, Song, Walcott, Gervinho, Chamberlain and Van Persie. Meanwhile, for AC Milan, expect Abbiati, Abate, Mexes, Silva, Antonini, Van Bommel, Muntari, Nocerino, Emanuelson, Ibrahimovic and Robinho.
Watch Arsenal vs Milan live stream via UEFA Match Centre here or check you local listing for other live broadcasts of the game.